Common Causes :
Variability in pipette tip size or shape
Embryo positioning inconsistencies
Inadequate zona opening techniques or tools
Resolution Path :
Use biopsy micropipettes from a reliable, precision-controlled manufacturer
Standardize embryo orientation and zona opening method (e.g., laser or acid Tyrode)
Ensure all embryologists follow a unified protocol for blastomere/TE extraction
Document every biopsy step for pattern recognition and optimization
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